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Certain peptides can continue producing biological effects even after the compound itself has largely been cleared from the body
Curcumin supplementation has been shown to restore brain-derived neurotrophic factor (BDNF) levels while regulating monoaminergic neurotransmission and mitigating multiple pathological processes including oxidative stress, neuroinflammation, -amyloid aggregation, tau pathology, and aluminum-induced neurotoxicity in both Alzheimers disease and depression models ( Current research underscores curcumins neuroprotective properties and its potential synergy with cognitive-behavioral therapy for managing depression and anxiety in Parkinsons disease (PD) patients (Singh et al., 2020
J Neurosci 42(45):85428555 Wang JH, Thampatty BP (2008) Mechanobiology of adult and stem cells
No lethal dose was established, suggesting a wide safety margin
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