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As yet, IUSCT has been performed on numerous human patients for various genetic disorders, notably osteogenesis imperfecta and alpha-thalassaemia (Le Blanc et al., At present, the future clinical application of IUSCT will likely ensue via two possible routes: A single IUSCT resulting in levels of engraftment adequate to treat SCD IUSCT that induces donor-specific tolerance, allowing for a second same-donor (non-myeloablative, non-immunosuppressive) transplant postnatally to boost engraftment to clinically relevant levels