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Bad Breath : The substances in tobacco contribute to persistent bad breath, often referred to as smokers breath. This unpleasant odor is caused by the accumulation of smoke particles and bacteria in the mouth

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One study, for example, treated Sprague Dawley rats treated with gestational nicotine (3 mg/kg/day) and found that PNE offspring (P35/P36) had altered myelin expression of myelin-related transcription and trophic factors that produced alterations in myelin gene expression and oligodendrocyte functioning [165]