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HO-1 catalyzes the degradation of heme into biliverdin, carbon monoxide (CO), and Fe + by reducing the heme-associated ferric iron (Fe + ) to Fe + (30)

Adjunctive approaches involving topical calcineurin inhibitors or corticosteroids in conjunction with phototherapy have yielded improved regimentation outcomes [209, 210], while emerging combinations with antioxidants and laser therapies offer additional therapeutic potential, albeit with limited clinical data to date [211]

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Carducci C, Birarelli M, Santagata P, Leuzzi V, Carducci C, Antonozzi I