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For instance, once they are identified, short sequences corresponding to broadly conserved CD4 and CD8 epitopes can often be added to vaccines encoding carefully designed structural antigens that are used to elicit B-cell responses

however, a delay in barrier establishment of other TJ proteins including occludin and claudins in the TJ was observed, indicating that ZO proteins have a role to play in the regulation of TJ assembly (Umeda et al., 2004)

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21 Degenerative IVD and discogenic pain Discogenic pain refers to pain induced by degenerative changes in the IVD, resulting in the early stages of disc degeneration