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Education and prevention programs that consider the interplay between these two behaviors could be more effective in reducing their prevalence and, consequently, lowering the burden of associated diseases

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Even though meta-analyses found no psychiatric side-effects, such as depression and bad mood, derived from smoking cessation 47,48 among general smoking quitters, some studies have detected an increased depression risk among those who attempt to quit unsuccessfully 49 and somatic adverse reactions among individuals with nicotine replacement therapy 50

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