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Ethical approval This research has been conducted using the UK Biobank Resource under application number 42468 and other large studies and consortia providing publicly available summary statistics (Additional file 1: Table S1 and Additional file 2: Fig

claimed that metabolic biomarkers, including methylation-redox, have 97% precision (sensitivity 72% and specificity 63%)

Funding This research was supported by the Ministry of Science and Technology of Taiwan (MOST 108-2221-E-002-163, MOST 109-2221-E-002-083) and National Taiwan University Hospital (107-EDN11, 108-N4406, 108EDN02, 109-O20, 109-S4579, 109-EDN11)

10.1097/shk.0000000000000390 178 WangJ.ZhuH.YangZ.LiuZ