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Those in the duloxetine group showed similar improvements in depression and no improvement in anxiety, but DID show reduction in pain

doi:10.1001/jamainternmed.2025.1794

"At one point, doctors were telling me not to eat too many carbohydrates because of my diabetes, but also not to eat too much protein because of my kidneys

[12] Gastric acid-suppressing agents (proton-pump inhibitors and H-receptor antagonists) diminish dietary B12 liberation from protein complexes, a pharmacodynamic interaction that can exacerbate underlying deficiency