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Its primary research application is as a pharmacological probe to selectively activate IGF1R in cell culture systems where IGFBP interference would otherwise complicate interpretation

Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor agonists

As in previous experiments in PWA mice, no gonadal effects were detected following treatment with the different drugs, except for a significant reduction in ovarian weight and an increase in uterus weight in E-treated mice (Suppl