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The peptide operates through a highly specific mechanism: it disrupts the interaction between FOXO4 transcription factor and the p53 tumor suppressor protein

"I just started taking a GLP-1 in pill form

A retrospective analysis of electronic health records by Wilding et al

But gastric sleeve may be the better choice if: Your BMI qualifies you for bariatric surgery You want a a more durable tool You have significant obesity-related medical problems You are tired of the recurring cost of GLP-1 drugs You do not want to rely on indefinite injections You have lost and regained weight repeatedly on diets or medication You want a treatment with a stronger long-term track record For many patients with obesity, gastric sleeve is not a last resort. It is simply the most logical long-term treatment