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It is class-wide counter-regulation: stopping removes the signal that was holding down a set-point the body still defends. The felt marker of the rebound is the return of food noise, which patients in the exit interviews reported as the first sign the loss was reversing. Metabolic loss tracks weight regain

Once it is in, you cannot take it back

Exenatide once weekly plus Dapagliflozin once daily versus exenatide or Dapagliflozin alone in patients with type 2 diabetes inadequately controlled with Metformin monotherapy (DURATION-8): a 28 week, multicentre, double-blind, phase 3, randomised controlled trial

doi: 10.3389/fnut.2022.718710