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These include water retention, joint discomfort, or changes in blood sugar regulation

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In an observational study that included data from 193,072 atrial fibrillation patients treated with DOACs (dabigatran, rivaroxaban, apixaban, and edoxaban), the various DOACs were associated with similar benefits, but apixaban was correlated with the lowest and dabigatran with the second-lowest risks of major and clinically relevant non-major bleeding events