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Injected vitamins are more effective than pill form supplements because they enter directly into the bloodstream, as opposed to first traveling through the digestive tract, then being absorbed into the bloodstream where they lose some of their potency

However, do not stop prescribed B12 injections or tablets for confirmed deficiency (such as pernicious anaemia) without consulting your GP, as this could lead to serious health consequences

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About 10% of tirzepatide participants had a heart-rate increase above 20 bpm during escalation, compared with 3% on placebo. A lean Japanese cohort reached +10 to +13 bpm, and 23% of Japanese participants at 15 mg crossed the abnormal-pulse threshold versus 7% of other participants, despite only 17% higher exposure. Lean and East Asian bodies showed greater cardiovascular sensitivity than exposure alone predicted