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JAMA 325:962970 Wood DE, Kazerooni EA, Aberle D et al (2022) NCCN Guidelines Insights: lung cancer screening, version 1.2022

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The model was used subsequently to predict differences in oral clearance between smoker and non-smoker cohorts in a Phase 1 clinical trial involving PF-2400013, a drug metabolized by CYP1A2

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