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41 (3 Suppl 2): S116-22

These individuals should consult with a doctor first before taking a vitamin B12 supplement

Expectations should be adjusted accordingly, with longer protocol durations (8 to 12 weeks), potentially higher doses, and understanding that improvement may reach 70 to 90 percent of normal rather than complete resolution

It is anticipated that by 2030, the number of individuals with DM will reach 643 million, escalating to 783 million by 2045, with a particularly heavy impact on low- and middle-income nations such as Iran, India, and South Africa [79]