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As recently as 2008, the female protagonist, April (Isla Fisher), in the romantic comedy Definitely, Maybe discusses the health benefits she feels she receives when smoking Natural American Spirit cigarettes over Marlboros, the choice of the male protagonist, Will (Ryan Reynolds)

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These changes have led to the rise of new brands and innovative manufacturing techniques, expanding the range of options available to fans

Smokeless Tobacco Co., according to Bonnie Herzog, managing director for beverage, tobacco and convenience-store research, Wells Fargo Securities LLC, New York