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Smoking rates over time Tobacco control efforts began in the 1960s, and global progress began with the passing of the WHO Framework Convention on Tobacco Control (FCTC) in 2005, which includes a range of recommended strategies for reducing tobacco use

Tumour cells with this genotype display a high level of plasticity, with an ASCL1-high/NEUROD1-low phenotype at early-stage disease and a NEUROD1-high/ASCL1-low phenotype in invasive late-stage tumours [148] (Table 1)

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