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NICE guidance on osteoarthritis (NG226: Osteoarthritis in over 16s: diagnosis and management) and obesity management (CG189: Obesity: identification, assessment and management) both acknowledge the musculoskeletal benefits of sustained weight loss, including improvements in knee and hip pain

The real question is whether the tradeoffs in quality assurance and regulatory oversight matter when making long-term health decisions

This mechanistic diversity suggests that GLP-1RAs could be repurposed to target complex, multifactorial disorders like schizophrenia, bipolar disorder, and bulimia nervosa, where current treatment options are limited or suboptimal

Recent research suggests both methods work better than regular oral supplements to help with age-related NAD+ decline