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Abbreviations AP-1: Activator protein-1 ALI: Airliquid interface AhR: Aryl hydrocarbon receptor ChIP-seq: Chromatin immunoprecipitation sequencing COPD: Chronic obstructive pulmonary disease CS: Cigarette smoke DEG: Differentially expressed gene FDR: False discovery rate FC: Fold change GSVA: Gene set variation analysis IEG: Immediate early gene CPM: Counts per million NNLS: Non-negative least squares Nrf2: Nuclear factor erythroid 2-related factor 2 PAH: Polycyclic aromatic hydrocarbons PBEC: Primary bronchial epithelial cells ROS: Reactive oxygen species SD: Standard deviation SVR: Support vector regression UMAP: Uniform manifold approximation and projection References Laniado-Laborn R