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However, combining multiple compounds that compete for the same receptors or cellular resources may require adjustment of dosing frequency for both agents

Blain in 2008 performed a randomised controlled trial

62 One trial that included 40 dogs compared a combination product providing 500 mg glucosamine hydrochloride and 300 mg chondroitin sulfate per 10 kg body weight, along with 70 mg of an anti-inflammatory herbal combination, 4 mg non-hydrolyzed type II collagen, and 18 mg hyaluronic acid per 10 kg of body weight, to placebo daily for 60 days