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doi: 10.1080/10408398.2015.1077195 26 AlmeidaHHSBarrosLBarreiraJCMCalhelhaRCHelenoSASayerCet al

Recommendations for safe prescribing include (Lewis 2013): Reduce medication dosages in general (consult your healthcare professional before making a change) Opioid analgesics, anxiolytics, and sedatives can cause or worsen hepatic encephalopathy symptoms and should be used cautiously Non-steroidal anti-inflammatory drugs (NSAIDs) can more readily cause renal failure and gastrointestinal bleeding in patients with cirrhosis and should generally be avoided Anticancer and immunomodulating drugs

Contrave specifically mentions the risk in children, adolescents, and young adults, while Wegovy advises monitoring for depression and suicidal thoughts in all individuals

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