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ESOPHAGUS (FOOD PIPE) The nicotine and other harmful chemicals in tobacco smoke can weaken the lower esophageal sphincter (LES), a muscular ring that separates the esophagus from the stomach

People are more likely to see an anti-smoking message if it is present in the form of a label right on the outside of the cigarette box they are holding, which is why these pack warning labels can be an effective form of advertising.1 They can be text-only, like the ones on Winston cigarettes boxes in the UK that say Smoking seriously harms you and others around you, or also include graphic images, such as the ones in Brazil that include images ranging from a stillborn baby to a dismembered and blackened foot

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How Tobacco Smoke Causes Disease: The biology and behavioral basis for smoking-attributable disease: a report of the Surgeon General