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This suggests a crucial role for Ru II -01 in modulating NRF2, depending on p53 status, for successful cancer cell responses to therapy ( Ru II -01 is hydrophobic in the cellular environment, which makes its efficient delivery to target sites difficultAccordingly, Ru II -01 was incorporated into hydrophobic compartments of various nanoassemblies, such as liposomes, micelles, and coacervate nanodroplets

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Pharmacokinetic studies can further develop the specified methodologies for targeted delivery of drugs from the nasal cavity to specific compartments

doi: 10.1038/s41443-022-00605-0 62 HamiltonTRCastroLSDelgado JdeCAssisPMSiqueiraAFMendesCMet al