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Importantly, this virus elicits lifelong infections by remaining latent in neurons from which sporadic viral reactivations may occur ( HSV-1 can enter the organism by interacting with skin epithelial cells, as the initial site of infection, by binding to heparan sulfate proteoglycans (HSPGs) on the cell surface thanks to the viral glycoprotein B (gB) and glycoprotein C (gC) ( Figure 1 ) ( Figure 1 ) ( Figure 1 ) ( Figure 1 ) ( Figure 2 )