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5 trials compared varenicline to bupropion finding varenicline to be superior by about 6.5% - it was 17% versus 24%

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On the other hand, most people who use marijuana don't smoke as much as a tobacco user, which could lower their odds for a problem

If the direct chronic disease harm from less-harmful, non-combustible smokeless tobacco/electronic cigarette/ANDS products is substantially less than from cigarettes/combustibles, those interested in tobacco control (broadly defined) have moved on to new arguments against tobacco use of any kind