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This is also available as a Shiny App at Discussion We have described a method to estimate the lung cancer risk for those using new tobacco products such as ECIGs and HTPs, based on North American and European data on biomarker levels for those smoking cigarettes and those using other ETPs, combined with recent estimates of the lung cancer RR of these products relative to individuals who do not use tobacco products

Cancer Statistics Review, 1975-(2005)

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A few studies have identified individuals with an inherited mutation in EGFR