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In several RCTs, GLP-1RAs, when used alone or in combination with other hypoglycemic agents including metformin, sulfonylurea, DPP-4 inhibitor, thiazolidinedione, and sodium-glucose cotransporter 2 inhibitor, showed superior or non-inferior blood glucose lowering ability compared to insulin treatment [64,65]

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The rates of depression were similar for the GLP-1RA group and sodium-glucose cotransporter-2 inhibitor (SGLT2i) group

Had faster re-epithelialization, increased CD31 + capillaries, iNOS, VEGF and PlGF expression, and reduced Nox4 + microvessels (in the full-thickness skin wound model)