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Cell Tissue Res 324:189202 Frade J, Pope S, Schmidt M, Dringen R, Barbosa R, Pocock J et al (2008) Glutamate induces release of glutathione from cultured rat astrocytesa possible neuroprotective mechanism

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These enzymes catalyze the reduction of H 2 O 2 to H 2 O through the coupled oxidation of GSH to GSSG, which is subsequently reduced back to GSH by glutathione reductase and NADPH.Other enzymes that require thiol-reducing equivalents, such as peroxiredoxins and glutaredoxins, also utilize glutathione as a reductant, restoring their oxidation-sensitive active sites to their reduced state by maintaining them in a Enzyme function

The absorption of glutathione and other substances from the gastrointestinal tract 38 and oral mucosa 39 has been the subject of some studies and it is now well known that orally administered glutathione cannot be relied upon for therapeutic purposes