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PA can be further oxidized by xanthine oxidase (XO) to form 5-hydroxy-pyrazinoic acid (5-OH-PA), a metabolite thought to be more hepatotoxic than PA
It seems that some smokers are aware that their habits are causing problems, as 17% of smokers said that someone has refused to date them because of the habit, and more than 1 in 5 (21%) smokers admitted to hiding their addiction from a partner
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Passengers often sat in smoke-filled cabins during flights, and smoking sections were often poorly separated from non-smoking areas, meaning tobacco smoke drifted freely throughout the cabin
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