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Although the therapeutic effect of resveratrol in treating COPD through activating SIRT1 and PGC-1 expression have been verified in animal models, a double-blind, randomized, placebo-controlled study revealed contrasting results ( Hesperidin, a flavanone glycoside widely found in the peel of citrus fruits, has various pharmacological activities, such as antioxidant (Imperatrice et al., 2022), anti-inflammatory (Han et al., 2023), and apoptosis inhibition (Wang S