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released the Frank Statement to Cigarette Smokers. In the piece, the tobacco companies denied the link to cancer, stating: We believe the products we make are not injurious to health. They sought to cast doubt on the independent studies findings related to lung cancer, saying There is no proof that cigarette smoking is one of the causes. Research suggests, however, that tobacco companies knew by the mid-1950s that their products were linked to cancer and were addictive

[18] [19] [20] [10] Physiology [edit] Carbon monoxide is produced naturally by many physiologically relevant enzymatic and non-enzymatic reactions [7] best exemplified by heme oxygenase catalyzing the biotransformation of heme (an iron protoporphyrin) into biliverdin and eventually bilirubin

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