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There is currently no official contraindication to taking Pepto-Bismol whilst on Wegovy, and no direct pharmacological interaction has been documented between bismuth subsalicylate (the active ingredient in Pepto-Bismol) and semaglutide

Synbiotics, a combination of prebiotics and probiotics, can further support gut health and weight loss goals

These modifications extend the half-life from minutes to days, making once-weekly dosing possible

About a third of the SELECT trial participants reported serious side effects, and about 17% in the group that took Wegovy and 8% of those who received a placebo left the study for that reason