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They are medical toolsno different from statins or blood pressure meds

Briefly, snap-frozen liver samples were weighed and homogenized in chloroform:methanol (2:1) solution, followed by the addition of saline and centrifugation at 10,000 rpm to achieve phase separation

Following the rate determining formation of 8-enolate , this intermediate shows only marginal stabilization over the corresponding transition state and evolves to 8-B4 in a barrierless step