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Globally, EBV causes more than 200,000 cancers annually, including endemic Burkitts lymphoma, Hodgkins lymphoma, non-Hodgkins lymphoma, central nervous system (CNS) lymphoma in patients with late-stage HIV infection, posttransplant lymphoproliferative disease (PTLD), nasopharyngeal carcinoma, and gastric carcinoma 5
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These observations suggest a significant contribution of CYPOR to NFT-induced Nrf2 activation in the HepG2 model, but also indicate that other cellular flavoprotein reductases are likely to be involved in the formation of the NFT radical anion and its subsequent activation of Nrf2 and synthesis of GCLC and glutathione
The modification to this peptide not only increases its stability but also enhances its activity
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