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The rationale for the first engineered GLP-1/GCGR co-agonist [114] originated from the observation that chronic administration of a water-soluble form of glucagon not only decreased body weight in mice with DIO, but also improved glucose tolerance with an efficacy similar to that obtained with exendin-4 [70]

Minimal and maximal signals were recorded in the presence of 5 mol/l ionomycin in 5 mmol/l EGTA/0 mmol/l Ca 2+ and 5 mmol/l Ca 2+ , respectively, at the end of the experiment

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Quantifying the sex-race/ethnicity-specific burden of obesity on incident diabetes mellitus in the United States, 2001 to 2016: MESA and NHANES