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XOR activity was significantly increased in the lung tissues of CS-induced mice, promoted the production of ROS, and involved in CS-induced pulmonary vascular endothelial cells apoptosis through the p53-mediated caspase-dependent apoptosis pathway [122]

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[74] Immune system [edit] Asbestos fibers have been shown to alter the function and secretory properties of macrophages, ultimately creating conditions which favour the development of mesothelioma