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doi: 10.1016/j.neurobiolaging.2012.04.009 53 KellyPMcCleanPLAckermannMKonerdingMAHlscherCMitchellCA

In fact, MMPs seem to be a key player in BBB disruption as they directly degrade TJ proteins and ECM components (78), macromolecules such as proteins exit the vasculature and enter the brain extracellular space, exerting an osmotic gradient, pulling water, and generating vasogenic edema