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The recommended dosage is one 5 gm sachet mixed in half a glass of lukewarm water, taken twice daily

The combination group had the most significant response, but all experienced significant reductions in skin luminosity differences between hyperpigmented and normal skin areas.Similarly, Handog et al found oral combination therapy with vitamins A, C, E, and procyanidin effective for treating Filipino women with melasma

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when the OFEL was hormonally primed (with a mixture of E2 + P4 + cAMP + XAV939) to reach the receptive WOI state, supporting the physiological relevance of this new embryo adhesion model