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Ia: Systematic review/meta-analysis Ib: Randomized controlled trial IIa: Non-randomized controlled trial or large-scale cohort study ( n 500) IIb: Analytic epidemiologic study: small-scale cohort, case-control, or cross-sectional III: Descriptive study: case report or case series report IV: Laboratory experiments and others Criteria for recommendations and consensus building A draft version of this document was distributed to each Working Group member for review and comments

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