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Acknowledgements This work was supported by the National Natural Science Foundation of China (81902422, 82403008), the China Postdoctoral Science Foundation (2024M762749), the Natural Science Foundation of Jiangsu Province (BK20231245, BK20250559), the program of Jiangsu Traditional Chinese Medicine Science and Technology Development (No.MS2024140), the key program of Jiangsu Provincial Health Commission (K2025009), Social Development Program of Yangzhou Science and Technology Bureau (No.YZ2025094), Yangzhou City Basic Research Program (Joint Special Project) - Health and Wellness Category (2024-2-08, 2025-2-08, and 2025-3-15), Natural Science Foundation of Minhang District (2025MHZ052)

Groups switched from WD to LD had a greater average relative abundance of Verrucomicrobia (represented solely by the genus Akkermansia )