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First, the SpragueDawley rats that were acquired were not fully skeletally mature at the time of harvest, which limits the generalizability of our findings to other mature animals or to adult human IVD physiology [66,67,68]

Thus our findings highlight the limitations of various smoking exposure indices and caution against drawing conclusions from a single indicator of smoking exposure

nitrite or nitrogen oxides)

Data extraction process and quality assessment The information gathered was synthetized in a table that included bibliographic information such as author, publication year, origin country, and study design information as well as population sample details such as sample size, age, and gender of participants