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Keywords: chronic obstructive pulmonary disease, glucose metabolism reprogramming, cigarette smoke, mitochondrial dysfunction, targeted metabolic intervention Introduction Chronic obstructive pulmonary disease (COPD) is a prevalent and heterogeneous respiratory disorder characterized by irreversible airflow limitation and chronic respiratory symptoms, with primary clinical phenotypes including chronic bronchitis and emphysema

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In Utah, adult cigarette smoking "reached a historic low of 5.8% in 2024," according to Utah's Department of Health and Human Services most recent data