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Physiological Reviews , 2005

The activation of NRF-2 in liver suppresses the synthesis of fatty acids [70], as observed in this study that included experimental feeding with 8-week-old NRF-2 null mice, and wild-type mice fed experimentally, observing the mRNA of sterol regulatory element-binding protein 1-c and fatty acid synthase as highly expressed in NRF-2 null [71], concluding that the protective action is afforded by the increase of AR

However, after prolonged or strenuous exercise, free radical production may overwhelm the system, and oxidative stress (an imbalance of free radical production and antioxidant defenses) can occur

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