The efficacy of perioperative tobacco interventions on long-term abstinence and the safety of smoking cessation less than 4 weeks before surgery is unclear
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Among the remaining nine studies in which nonfatal myocardial infarctions did occur, five studies reported a higher number of myocardial infarctions in the nicotine group than in the non-nicotine control group (32, 38, 63, 65, 72), while three studies reported a lower number of nonfatal myocardial infarctions in the nicotine group (33, 35, 39)
Plus, smokers with underlying mental health issues, like substance-use disorder, depression, anxiety, schizophrenia and bipolar disorder, respond favorably to varenicline
