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Because the estimate had a wide confidence interval, we opted to begin the main study with an adaptive design (Chow & Chang, 2011)

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Higher levels of calcification can stabilize large plaques, but calcium is also linked to fragmented or microcalcifications, which also cause coronary events.[ref] Genetic variants linked to higher serum calcium levels are also linked to an increased risk for CAD.[ref] Triggers of endothelial injury: I want to circle back to the inflammation of the endothelium