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In comparison, 7,293 individuals (8.0%) with an estimated HbA1c advantage on GLP1-RA showed a 16 mmol/mol drop in HbA1c, whereas SGLT2i recipients had a nine mmol/mol decrease in HbA1c

PGC-1a is a nuclear and mitochondrial transcriptional coactivator inducing the expression of a large set of genes in response to metabolic and physiological stimuli, such as physical exercise [73,74]