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Among smokeless tobacco users, 47.2% had reported previous diagnoses of cardiovascular disease, as had 40.4% of cigarette smokers and 34.7% of nontobacco users

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This analysis specifically highlighted that the amount of oxidized proteins following exposure to heated tobacco products was significantly lower compared to traditional cigarettes . In other words, heated tobacco products present a different toxicity profilenot only due to a reduction in harmful substances but also because they release different compounds that have distinct effects on corneas and cells