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INTRODUCTION Hyperuricemia (HUA) is a metabolic disease caused by abnormal purine metabolism resulting in abnormally high blood uric acid levels, and several studies have confirmed that baseline uric acid levels are a major predictor of gout attacks 1

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Compared to placebo the EC smoking increased systolic BP by 9,6 4,1 mmHg, diastolic BP by 7.1 3.9 mmHg and heart rate by 16,4 13 beat per minute