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Leptin binds to the long-form leptin receptor (OB-Rb, LepR hereafter), which is highly expressed in the hypothalamus, and signals through JAK-STAT pathway ( 1, 15 )

Trial participants on the highest dose lost roughly 15% of body weight over 68 weeks, a number so far above what any prior pharmacotherapy had achieved that endocrinologists who had spent careers managing modest expectations had to recalibrate the conversation in real time

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There was no difference in the (low) numbers of confirmed hypoglycemia between DPP-4 inhibition and placebo and the occurrence of adverse events did not differ between the study groups except a slight increase in gastrointestinal adverse events in one of the studies ( Figure 7 Placebo-Controlled Studies With DPP-4 Inhibition as Add-on to Ongoing Metformin Therapy The DPP-4 inhibitors were also examined as add-on to on-going metformin in subjects with type 2 diabetes in 2426 week studies with a total number of 3,216 subjects [Table 2