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The hyperpolarization of POU2F3 and FOXI1 KO cultures could result from disruption of ionocyte-enriched CFTR, which would be consistent with CFTR mutant/KO data from mice and human cell cultures 61,62 , as well as nasal potential difference measurements in individuals with cystic fibrosis 63

Interventions for SUD can include: detoxification, or removal of the substance from the system psychotherapy, or talk therapy joining support groups medications inpatient rehabilitation Some starting points for help with SUD include Narcotics Anonymous or SMART Recovery

Gastroenterology 149 , 13921398 (2015)

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